Anti-SRRT IP antibody [SAA0231] (STJA0018746)

SKU:
STJA0018746
£378.50 - £1,632.50
Free Shipping
Processing The item has been added

Host: Mouse
Applications: ELISA/IF/IP
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS
Short Description : Mouse monoclonal antibody anti-Serrate Rna Effector Molecule Homolog is suitable for use in ELISA, Immunofluorescence and Immunoprecipitation research applications.
Clonality : Monoclonal
Clone ID : SAA0231
Conjugation: Unconjugated
Isotype: IgG2a
Formulation: 0.01M PBS
Purification: Protein A/G purified from cell culture supernatant
Concentration: 1 mg/mL
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months
Gene Symbol: SRRT
Gene ID: 51593
Uniprot ID: SRRT_HUMAN
Function Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA).however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription.
Protein Name Serrate Rna Effector Molecule Homolog
Arsenite-Resistance Protein 2
Database Links Reactome: R-HSA-6807505
Reactome: R-HSA-72163
Cellular Localisation Nucleus
Nucleoplasm
Cytoplasm
Predominantly Nuclear
Shuttles Between The Nucleus And The Cytoplasm In A Crm1-Dependent Way
Alternative Antibody Names Anti-Serrate Rna Effector Molecule Homolog antibody
Anti-Arsenite-Resistance Protein 2 antibody
Anti-SRRT antibody
Anti-ARS2 antibody
Anti-ASR2 antibody

Information sourced from Uniprot.org