Anti-SRRT antibody (623-872) (STJ11100951)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SRRT (623-872) antibody for use in IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SRRT |
| Gene ID | 51593 |
| Uniprot ID | SRRT_HUMAN |
| Immunogen Region | 623-872 |
| Immunogen Sequence | DYYNTCEYPNEDEMPNRCGI IHVRGPMPPNRISHGEVLEW QKTFEEKLTPLLSVRESLSE EEAQKMGRKDPEQEVEKFVT SNTQELGKDKWLCPLSGKKF KGPEFVRKHIFNKHAEKIEE VKKEVAFFNNFLTDAKRPAL PEIKPAQPPGPAQSLTPGLP YPHQTPQGLMPYGQPRPPIL GYGAGAVRPAVPTGGPPYPH APYGAGRGNYDAFRGQGGYP GKPRNRMVRGDPRAIVEYR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 623-872 of human SRRT (NP_001122325.1). |
Additional Info
| Tissue Specificity | Ubiquitously expressed. |
| Function | Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA).however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription. |
| Protein Name | Serrate Rna Effector Molecule HomologArsenite-Resistance Protein 2 |
| Database Links | Reactome: R-HSA-6807505Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusNucleoplasmCytoplasmPredominantly NuclearShuttles Between The Nucleus And The Cytoplasm In A Crm1-Dependent Way |
| Alternative Antibody Names | Anti-Serrate Rna Effector Molecule Homolog antibodyAnti-Arsenite-Resistance Protein 2 antibodyAnti-SRRT antibodyAnti-ARS2 antibodyAnti-ASR2 antibody |
Information sourced from Uniprot.org