| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SRP54 (196-455) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SRP54 |
| Gene ID: |
6729 |
| Uniprot ID: |
SRP54_HUMAN |
| Immunogen Region: |
196-455 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 196-455 of human SRP54 (NP_001139754.1). |
| Immunogen Sequence: |
VIVTKLDGHAKGGGALSAVA ATKSPIIFIGTGEHIDDFEP FKTQPFISKLLGMGDIEGLI DKVNELKLDDNEALIEKLKH GQFTLRDMYEQFQNIMKMGP FSQILGMIPGFGTDFMSKGN EQESMARLKKLMTIMDSMND QELDSTDGAKVFSKQPGRIQ RVARGSGVSTRDVQELLTQY TKFAQMVKKMGGIKGLFKGG DMSKNVSQSQMAKLNQQMAK MMDPRVLHHMGGMAGLQSM |
| Function | Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development. |
| Protein Name | Signal Recognition Particle Subunit Srp54Signal Recognition Particle 54 Kda Protein |
| Database Links | Reactome: R-HSA-1799339 |
| Cellular Localisation | Nucleus SpeckleCytoplasmEndoplasmic Reticulum |
| Alternative Antibody Names | Anti-Signal Recognition Particle Subunit Srp54 antibodyAnti-Signal Recognition Particle 54 Kda Protein antibodyAnti-SRP54 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
