| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | SRCAP |
| Gene ID: | 10847 |
| Uniprot ID: | SRCAP_HUMAN |
| Immunogen Region: | 1-260 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human SRCAP (NP_006653.2). |
| Immunogen Sequence: | MQSSPSPAHPQLPVLQTQMV SDGMTGSNPVSPASSSSPAS SGAGGISPQHIAQDSSLDGP PGPPDGATVPLEGFSLSQAA DLANKGPKWEKSHAEIAEQA KHEAEIETRIAELRKEGFWS LKRLPKVPEPPRPKGHWDYL CEEMQWLSADFAQERRWKRG VARKVVRMVIRHHEEQRQKE ERARREEQAKLRRIASTMAK DVRQFWSNVEKVVQFKQQSR LEEKRKKALDLHLDFIVGQ |
| Function | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. |
| Protein Name | Helicase SrcapDomino Homolog 2Snf2-Related Cbp Activator |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Helicase Srcap antibodyAnti-Domino Homolog 2 antibodyAnti-Snf2-Related Cbp Activator antibodyAnti-SRCAP antibodyAnti-KIAA0309 antibody |
Information sourced from Uniprot.org