| Short Description : | Rabbit polyclonal SRA1 (1-100) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SRA1 |
| Gene ID: | 10011 |
| Uniprot ID: | SRA1_HUMAN |
| Immunogen Region: | 1-100 |
| Immunogen Sequence: | MTRCPAGQAEVEMAELYVKP GNKERGWNDPPQFSYGLQTQ AGGPRRSLLTKRVAAPQDGS PRVPASETSPGPPPMGPPPP SSKAPRSPPVGSGPASGVEP |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SRA1 (NP_001030312.2). |
| Tissue Specificity | Highly expressed in liver and skeletal muscle and to a lesser extent in brain. Also expressed in both normal and tumorigenic breast epithelial cell lines. Significantly up-regulated in human tumors of the breast, ovary, and uterus. |
| Function | Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis. |
| Protein Name | Steroid Receptor Rna Activator 1Steroid Receptor Rna Activator ProteinSrap |
| Database Links | |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Steroid Receptor Rna Activator 1 antibodyAnti-Steroid Receptor Rna Activator Protein antibodyAnti-Srap antibodyAnti-SRA1 antibodyAnti-PP7684 antibody |
Information sourced from Uniprot.org
