| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SPRY3 |
| Gene ID: | 10251 |
| Uniprot ID: | SPY3_HUMAN |
| Immunogen Region: | C-Term |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human SPRY3 (NP_005831.1). |
| Immunogen Sequence: | TDDEDNCADEPCSCGPSSCF VRWAAMSLISLFLPCLCCYL PTRGCLHLCQQGYDSLRRPG CRCKRHTNTVCRKISSGSAP FPKAQEKSV |
| Tissue Specificity | Widely expressed.particularly in the fetal tissues. Expressed in the brain with expression the highest in Purkinje cells in the cerebellum (at protein level). Expressed in the myocardium of the heart. |
| Function | Inhibits neurite branching, arbor length and neurite complexity. Inhibits EGF-mediated p42/44 ERK signaling. Negatively regulates the MAPK cascade, resulting in a reduction of extracellular matrix protein accumulation. May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. |
| Protein Name | Protein Sprouty Homolog 3Spry-3Sprouty Rtk Signaling Antagonist 3Sprouty3 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Protein Sprouty Homolog 3 antibodyAnti-Spry-3 antibodyAnti-Sprouty Rtk Signaling Antagonist 3 antibodyAnti-Sprouty3 antibodyAnti-SPRY3 antibody |
Information sourced from Uniprot.org