Sprouty 2 antibody western blot HeLa lysates STJA0036736

Anti-Sprouty 2 antibody [R06-7N6] (STJA0036736)

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STJA0036736
£133.50 - £281.50
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Short Description :Rabbit monoclonal anti-Sprouty 2 for use in WB, IHC-P, ICC, IF and IP in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications:WB/IHC-P/ICC/IF/IP
Host:Rabbit
Reactivity:Human/Rat
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :R06-7N6
Isotype:IgG
Conjugation:Unconjugated
Purification:Affinity Chromatography
Dilution Range:WB 1:500-1:1000
IHC 1:50-1:100
IF 1:50-1:200
IP 1:50
Formulation:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Instruction:Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol:SPRY2
Gene ID:10253
Uniprot ID:SPY2_HUMAN
Immunogen:A synthesized peptide derived from human Sprouty 2
Post Translational Modifications Cleaved at Pro-144 by the prolyl endopeptidase FAP (seprase) activity (in vitro).
Function Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2. Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis. Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells. Inhibits CBL/C-CBL-mediated EGFR ubiquitination.
Protein Name Protein Sprouty Homolog 2
Spry-2
Database Links Reactome: R-HSA-1295596
Reactome: R-HSA-182971
Cellular Localisation Cytoplasm
Cytoskeleton
Cell Projection
Ruffle Membrane
Associated With Microtubules In Unstimulated Cells But Is Translocated To The Membrane Ruffles In Cells Stimulated With Egf (Epidermal Growth Factor)
Alternative Antibody Names Anti-Protein Sprouty Homolog 2 antibody
Anti-Spry-2 antibody
Anti-SPRY2 antibody

Information sourced from Uniprot.org

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