| Short Description : | Rabbit polyclonal anti-Sprouty-related, EVH1 domain-containing protein 1 (210-290 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SPRED1 |
| Gene ID: | 161742 |
| Uniprot ID: | SPRE1_HUMAN |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 210-290 |
| Immunogen Region: | 210-290 aa |
| Specificity: | SPRE1 Polyclonal Antibody detects endogenous levels of protein. |
| Post Translational Modifications | Palmitoylated by ZDHHC17/HIP14. Phosphorylated on tyrosine. Ubiquitinated. |
| Function | Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow. Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2. Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin. Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells. |
| Protein Name | Sprouty-Related - Evh1 Domain-Containing Protein 1Spred-1Hspred1 |
| Database Links | Reactome: R-HSA-5658442Reactome: R-HSA-5658623Reactome: R-HSA-6802953 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinMembraneCaveolaNucleusLocalized In Cholesterol-Rich Membrane Raft/Caveola Fractions |
| Alternative Antibody Names | Anti-Sprouty-Related - Evh1 Domain-Containing Protein 1 antibodyAnti-Spred-1 antibodyAnti-Hspred1 antibodyAnti-SPRED1 antibody |
Information sourced from Uniprot.org
