Anti-SPRED1 antibody (210-290 aa) (STJ192503)

SKU:
STJ192503
£48.00 - £252.00
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Sprouty-related, EVH1 domain-containing protein 1 (210-290 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SPRED1
Gene ID: 161742
Uniprot ID: SPRE1_HUMAN
Immunogen Region: 210-290 aa
Specificity: SPRE1 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from the human protein at the amino acid range 210-290
Post Translational Modifications Palmitoylated by ZDHHC17/HIP14. Phosphorylated on tyrosine. Ubiquitinated.
Function Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow. Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2. Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin. Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells.
Protein Name Sprouty-Related - Evh1 Domain-Containing Protein 1
Spred-1
Hspred1
Database Links Reactome: R-HSA-5658442
Reactome: R-HSA-5658623
Reactome: R-HSA-6802953
Cellular Localisation Cell Membrane
Peripheral Membrane Protein
Membrane
Caveola
Nucleus
Localized In Cholesterol-Rich Membrane Raft/Caveola Fractions
Alternative Antibody Names Anti-Sprouty-Related - Evh1 Domain-Containing Protein 1 antibody
Anti-Spred-1 antibody
Anti-Hspred1 antibody
Anti-SPRED1 antibody

Information sourced from Uniprot.org

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