| Host: |
Rabbit |
| Applications: |
ELISA/IHC/IP/WB |
| Reactivity: |
D.melanogaster/Monkey/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SPNS2 (482-499) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Purification: |
Affinity Purified |
| Concentration: |
0.65 µg/µl |
| Dilution Range: |
WB: 1:500DB: 1:10, 000ELISA: 1:10, 000IP: 1:200IHC: 1:50-1:150 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
SPNS2 |
| Gene ID: |
124976 |
| Uniprot ID: |
SPNS2_HUMAN |
| Immunogen Region: |
482-499 |
| Immunogen: |
Synthetic amidated peptide from Human SPNS2 protein, the epitope location is extracytoplasmic between TMD9 and TMD10. Human, Mouse: amino acids 482-499 D. melanogaster: amino acids 373-389 The peptide was synthesized at 90% HPLC purity, covalently mo |
| Function | Lipid transporter that specifically mediates export of sphingosine-1-phosphate (sphing-4-enine 1-phosphate, S1P) and sphinganine-1-phosphate in the lymph, thereby playing a role in lymphocyte trafficking. S1P is a bioactive signaling molecule that regulates many physiological processes important for the development and for the immune system. Regulates levels of S1P and the S1P gradient that exists between the high circulating concentrations of S1P and low tissue levels that control lymphocyte trafficking. Required for the egress of T-cells from lymph nodes during an immune response by mediating S1P secretion, which generates a gradient that enables activated T-cells to access lymph. Also required for the egress of immature B-cells from the bone marrow. In contrast, not involved in S1P release from red blood cells. Involved in auditory function. S1P release in the inner ear is required for maintenance of the endocochlear potential in the cochlea. In addition to export, also able to mediate S1P import. |
| Protein Name | Sphingosine-1-Phosphate Transporter Spns2Protein Spinster Homolog 2 |
| Database Links | Reactome: R-HSA-1660661 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndosome Membrane |
| Alternative Antibody Names | Anti-Sphingosine-1-Phosphate Transporter Spns2 antibodyAnti-Protein Spinster Homolog 2 antibodyAnti-SPNS2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
