| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Spindlin-1 (111-160 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SPIN1 |
| Gene ID: | 10927 |
| Uniprot ID: | SPIN1_HUMAN |
| Immunogen Region: | 111-160 aa |
| Specificity: | Spindlin-1 Polyclonal Antibody detects endogenous levels of Spindlin-1 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human SPIN1 at the amino acid range 111-160 |
| Post Translational Modifications | Phosphorylated during oocyte meiotic maturation. |
| Function | Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway. Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes. May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption. |
| Protein Name | Spindlin-1Ovarian Cancer-Related ProteinSpindlin1 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Antibody Names | Anti-Spindlin-1 antibodyAnti-Ovarian Cancer-Related Protein antibodyAnti-Spindlin1 antibodyAnti-SPIN1 antibodyAnti-OCR antibodyAnti-SPIN antibody |
Information sourced from Uniprot.org