| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Speedy protein A is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SPDYA |
| Gene ID: | 245711 |
| Uniprot ID: | SPDYA_HUMAN |
| Specificity: | This antibody detects endogenous levels of SPDYA at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human SPDYA |
| Function | Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2. Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation. Mediates cell survival during the DNA damage process through activation of CDK2. |
| Protein Name | Speedy Protein ARapid Inducer Of G2/M Progression In Oocytes ARingo AHspy/Ringo ASpeedy-1Spy1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Speedy Protein A antibodyAnti-Rapid Inducer Of G2/M Progression In Oocytes A antibodyAnti-Ringo A antibodyAnti-Hspy/Ringo A antibodyAnti-Speedy-1 antibodyAnti-Spy1 antibodyAnti-SPDYA antibodyAnti-SPDY1 antibodyAnti-SPY1 antibody |
Information sourced from Uniprot.org