| Function | Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity. (Microbial infection) Required for the post-translational processing of proteins involved in virion assembly and secretion from flaviviruses such as West Nile virus (WNV), Japanese encephalitis virus (JEV), Dengue virus type 2 (DENV-2), Yellow Fever virus (YFV), Zika virus (ZIKV) and hepatitis C virus (HCV). Plays a key role in the post-translational processing of flaviviral structural proteins prM, E, and NS1. In HCV, it is involved in virion assembly where it promotes the interaction between HCV virus proteins NS2 and E2. |
| Protein Name | Signal Peptidase Complex Subunit 1Microsomal Signal Peptidase 12 Kda SubunitSpase 12 Kda Subunit |
| Database Links | Reactome: R-HSA-1799339Reactome: R-HSA-381771Reactome: R-HSA-400511Reactome: R-HSA-422085Reactome: R-HSA-9828806 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Signal Peptidase Complex Subunit 1 antibodyAnti-Microsomal Signal Peptidase 12 Kda Subunit antibodyAnti-Spase 12 Kda Subunit antibodyAnti-SPCS1 antibodyAnti-SPC12 antibodyAnti-HSPC033 antibody |
Information sourced from Uniprot.org
