Anti-SPATA13 antibody (STJA0008804)

SKU:
STJA0008804
€61.25 - €326.25
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal anti-Spermatogenesis-associated protein 13 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SPATA13
Gene ID: 221178
Uniprot ID: SPT13_HUMAN
Specificity: This antibody detects endogenous levels of SPATA13 at Human, Mouse
Immunogen: Synthesized peptide derived from human SPATA13
Function Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
Protein Name Spermatogenesis-Associated Protein 13
Apc-Stimulated Guanine Nucleotide Exchange Factor 2
Asef2
Database Links Reactome: R-HSA-9013148
Reactome: R-HSA-9013149
Cellular Localisation Cytoplasm
Cell Projection
Filopodium
Lamellipodium
Ruffle Membrane
Podosome
Accumulates In The Lamellipodium And Ruffle Membrane In Response To Hepatocyte Growth Factor (Hgf) Treatment
Localized To The Core Of Myotube Podosomes
Alternative Antibody Names Anti-Spermatogenesis-Associated Protein 13 antibody
Anti-Apc-Stimulated Guanine Nucleotide Exchange Factor 2 antibody
Anti-Asef2 antibody
Anti-SPATA13 antibody

Information sourced from Uniprot.org

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