Anti-SPART antibody (303-353) (STJA0006497)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human SPG20 AA range: 303-353
General Information
| Short Description | Rabbit polyclonal anti-Spartin (303-353) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SPART |
| Gene ID | 23111 |
| Uniprot ID | SPART_HUMAN |
| Immunogen | Synthesized peptide derived from human SPG20 AA range: 303-353 |
| Immunogen Region | 303-353 |
| Specificity | This antibody detects endogenous levels of human SPG20 |
Additional Info
| Post Translational Modifications | Ubiquitinated.ubiquitination does not require ITCH and WWP1. |
| Function | Lipophagy receptor that plays an important role in lipid droplet (LD) turnover in motor neurons. Localizes to LDs and interacts with components of the autophagy machinery, such as MAP1LC3A/C proteins to deliver LDs to autophagosomes for degradation via lipophagy. Lipid transfer protein required for lipid droplet degradation, including by lipophagy. Can bind and transfer all lipid species found in lipid droplets, from phospholipids to triglycerides and sterol esters but the direction of lipid transfer by spartin and its cargos are unknown. May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis. |
| Protein Name | SpartinSpastic Paraplegia 20 ProteinTrans-Activated By Hepatitis C Virus Core Protein 1 |
| Database Links | |
| Cellular Localisation | CytoplasmMidbodyLipid DropletTransiently Associated With EndosomesColocalized With Ist1 To The Ends Of Flemming Bodies During Cytokinesis |
| Alternative Antibody Names | Anti-Spartin antibodyAnti-Spastic Paraplegia 20 Protein antibodyAnti-Trans-Activated By Hepatitis C Virus Core Protein 1 antibodyAnti-SPART antibodyAnti-KIAA0610 antibodyAnti-SPG20 antibodyAnti-TAHCCP1 antibody |
Information sourced from Uniprot.org