| Post Translational Modifications | Phosphorylated by AURKA. |
| Function | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes. Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2. In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis. May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU. |
| Protein Name | Sperm-Associated Antigen 5AstrinDeepestMitotic Spindle-Associated Protein P126Map126 |
| Cellular Localisation | CytoplasmCytoskeletonSpindleSpindle PoleChromosomeCentromereKinetochoreMidbodyMicrotubule Organizing CenterCentrosomeCytoplasmic GranuleCentriolar SatelliteColocalizes With Pcm1 At Centriolar Satellites Throughout The Cell CycleIn A Punctate Pattern In Interphase CellsDuring MitosisDetected At Spindle Poles During ProphaseThroughout The Spindle In Metaphase And AnaphaseAnd At Midzone Microtubules In Anaphase And TelophaseEfficient Targeting To The Mitotic Spindle May Depend Upon Phosphorylation By Gsk3bDetected On Kinetochores Of Chromosomes That Have CongressedThe Astrin (Spag5)-Kinastrin (Skap) Complex Localizes To The Microtubule Plus EndsIn Non-Mitotic Non-Stressed CellsShows A Microtubuli PatternIn Arsenite-Stressed CellsAccumulates In Stress Granules |
| Alternative Antibody Names | Anti-Sperm-Associated Antigen 5 antibodyAnti-Astrin antibodyAnti-Deepest antibodyAnti-Mitotic Spindle-Associated Protein P126 antibodyAnti-Map126 antibodyAnti-SPAG5 antibody |
Information sourced from Uniprot.org
