Anti-SPA1/SIPA1 antibody (C-Term) (STJ70500)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-SPA1/SIPA1 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx. 150kDa band observed in Human lysates of EBV-immortilized lymphoblastoid (calculated MW of 112kDa according to NP_694985.28 and NP_006738.2). The observed molecular weight corr |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | SIPA1 |
| Gene ID | 6494 |
| Uniprot ID | SIPA1_HUMAN |
| Accession Number | NP_694985.28; NP_006738.3 |
| Immunogen Region | C-Term |
| Immunogen Sequence | ASKQLGSPTADLA |
| Specificity | Both variants represent identical protein (NP_694985.28 and NP_006738.3). |
Additional Info
| Function | GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state. Affects cell cycle progression. |
| Protein Name | Signal-Induced Proliferation-Associated Protein 1Sipa-1Gtpase-Activating Protein Spa-1P130 Spa-1 |
| Database Links | Reactome: R-HSA-392517 |
| Cellular Localisation | NucleusCytoplasmPerinuclear RegionEndomembrane SystemPeripheral Membrane ProteinMostly Localized In The Perinuclear Membraneous Region |
| Alternative Antibody Names | Anti-Signal-Induced Proliferation-Associated Protein 1 antibodyAnti-Sipa-1 antibodyAnti-Gtpase-Activating Protein Spa-1 antibodyAnti-P130 Spa-1 antibodyAnti-SIPA1 antibodyAnti-SPA1 antibody |
Information sourced from Uniprot.org