| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SP7 |
| Gene ID: | 121340 |
| Uniprot ID: | SP7_HUMAN |
| Immunogen Region: | 333-376 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 333-376 of human SP7 (NP_001166938.1). |
| Immunogen Sequence: | KRFTRSDELERHVRTHTREK KFTCLLCSKRFTRSDHLSKH QRTH |
| Tissue Specificity | Restricted to bone-derived cell. |
| Post Translational Modifications | Ubiquitination at leads to proteasomal degradation. SP7 is a short-live protein with an endogenous half-life of approximately 12 hours. Propionylated. Depropionylation at Lys-371 by SIRT7 activates transcription factor activity and positively regulates bone formation by osteoblasts. |
| Function | Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences. |
| Protein Name | Transcription Factor Sp7Zinc Finger Protein Osterix |
| Database Links | Reactome: R-HSA-8940973 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Sp7 antibodyAnti-Zinc Finger Protein Osterix antibodyAnti-SP7 antibodyAnti-OSX antibody |
Information sourced from Uniprot.org