| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-Transcription Factor Sox-4 (350-450) is suitable for use in Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S4822RM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:2000-1:20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SOX4 |
| Gene ID: |
6659 |
| Uniprot ID: |
SOX4_HUMAN |
| Immunogen Region: |
350-450 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 350-450 of human SOX4 (NP_003098.1). |
| Immunogen Sequence: |
AAGRSPADHRGYASLRAASP APSSAPSHASSSASSHSSSS SSSGSSSSDDEFEDDLLDLN PSSNFESMSLGSFSSSSALD RDLDFNFEPGSGSHFEFPDY C |
| Tissue Specificity | Testis, brain, and heart. |
| Post Translational Modifications | Acetylation at Lys-95 by KAT5 promotes the transcription activator activity and is required during myoblast differentiation. Acetylation by KAT5 abolishes the interaction between SOX4 and HDAC1 and switches SOX4 into a transcriptional activator. |
| Function | Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif. Required for IL17A-producing Vgamma2-positive gamma-delta T-cell maturation and development, via binding to regulator loci of RORC to modulate expression. Involved in skeletal myoblast differentiation by promoting gene expression of CALD1. |
| Protein Name | Transcription Factor Sox-4 |
| Database Links | Reactome: R-HSA-3769402 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Sox-4 antibodyAnti-SOX4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
