| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SOX30 |
| Gene ID: | 11063 |
| Uniprot ID: | SOX30_HUMAN |
| Immunogen Region: | 604-753 |
| Immunogen Sequence: | FGTPPRFSFHHPYFLPGPHY FPSSTCPYSRPPFGYGNFPS SMPECLSYYEDRYPKHEGIF STLNRDYSFRDYSSECTHSE NSRSCENMNGTSYYNSHSHS GEENLNPVPQLDIGTLENVF TAPTSTPSSIQQVNVTDSDE EEEEKVLRDL |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 604-753 of human SOX30 (NP_848511.1). |
| Function | Acts both as a transcriptional activator and a repressor. Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif. Binds to its own promoter and activates its own transcription. Required to activate the expression of postmeiotic genes involved in spermiogenesis. Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling. Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4. |
| Protein Name | Transcription Factor Sox-30 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmEnriched At The Chromocenter |
| Alternative Antibody Names | Anti-Transcription Factor Sox-30 antibodyAnti-SOX30 antibody |
Information sourced from Uniprot.org
