| Tissue Specificity | Expressed in the lung (at protein level). Expressed in testes (at protein level). Expressed in preleptotene spermatocytes, round spermatids, and elongated spermatids in the testis (at protein level). Expressed in pachytene spermatocytes during stages 3 to 8 of spermatogenesis (at protein level). Increased expression in diplotene spermatocytes at stage 9-11 and in metaphase spermatocytes or secondary spermatocytes at stage 12. Expressed in ovaries. |
| Function | Acts both as a transcriptional activator and a repressor. Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif. Binds to its own promoter and activates its own transcription. Required to activate the expression of postmeiotic genes involved in spermiogenesis. Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling. Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4. |
| Protein Name | Transcription Factor Sox-30 |
| Cellular Localisation | NucleusCytoplasmEnriched At The Chromocenter |
| Alternative Antibody Names | Anti-Transcription Factor Sox-30 antibodyAnti-Sox30 antibody |
Information sourced from Uniprot.org
