| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SOX30 (1-150) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Sox30 |
| Gene ID: |
214105 |
| Uniprot ID: |
SOX30_MOUSE |
| Immunogen Region: |
1-150 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of mouse SOX30 (NP_775560.1). |
| Immunogen Sequence: |
MERARPEPPPPPPPPPRQPP RPTPPRPLRPAPPAQPVEAA TFRAAAAERSQSPSAQATAA MAAVASSCGEAAAAGAQAAG TRRLLQVKPEQVLLLPPGGP GVPPAPDEGAAAAAAAAAAA ASSAQARLLQLRPELLLLPP QSAADGGPCR |
| Tissue Specificity | Expressed in the lung (at protein level). Expressed in testes (at protein level). Expressed in preleptotene spermatocytes, round spermatids, and elongated spermatids in the testis (at protein level). Expressed in pachytene spermatocytes during stages 3 to 8 of spermatogenesis (at protein level). Increased expression in diplotene spermatocytes at stage 9-11 and in metaphase spermatocytes or secondary spermatocytes at stage 12. Expressed in ovaries. |
| Function | Acts as both a transcriptional activator and repressor. Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif. Binds to its own promoter and activates its own transcription. Required to activate the expression of postmeiotic genes involved in spermiogenesis. Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling. Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4. |
| Protein Name | Transcription Factor Sox-30 |
| Cellular Localisation | NucleusCytoplasmEnriched At The Chromocenter |
| Alternative Antibody Names | Anti-Transcription Factor Sox-30 antibodyAnti-Sox30 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
