| Host: | Goat |
| Applications: | Pep-ELISA/IF/WB |
| Reactivity: | Human/Mouse/Rat/Dog/Cow/Pig |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-SOX10 (Internal) is suitable for use in ELISA, Immunofluorescence and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 50kDa band observed in Human Brain (Cerebellum) and approx. 52kDa in Mouse Brain lysates (calculated MW of 49.9kDa according to Human NP_008872.1 and Mouse NP_035567.1). Recomm |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | SOX10 |
| Gene ID: | 6663 |
| Uniprot ID: | SOX10_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_008872.1 |
| Immunogen Sequence: | DAKAQVKTETAGPQ |
| Function | Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3. Transcriptional activator of MBP, via binding to the gene promoter. |
| Protein Name | Transcription Factor Sox-10 |
| Database Links | Reactome: R-HSA-9619665Reactome: R-HSA-9764302Reactome: R-HSA-9824585Reactome: R-HSA-9856649 |
| Cellular Localisation | CytoplasmNucleusMitochondrion Outer MembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-Transcription Factor Sox-10 antibodyAnti-SOX10 antibody |
Information sourced from Uniprot.org