• Immunohistochemistry of rat brain with Anti-SOX10 primary antibody (STJ503086) at 1:50 dilution in buffer. Section was treated with DAB and Haematoxylin stain. Magnification is at 40X.

Anti-SOX10 antibody (10-60) (STJ503086)

SKU:
STJ503086-100

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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Monkey/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-SOX10 (10-60) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.55-0.75 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:150
IHC: 1:50-1:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: SOX10
Gene ID: 6663
Uniprot ID: SOX10_HUMAN
Immunogen Region: 10-60
Immunogen: Synthetic peptide taken within amino acid region 10-60 on human Transcription Factor SOX-10 protein.
Tissue Specificity Expressed in fetal brain and in adult brain, heart, small intestine and colon.
Function Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3. Transcriptional activator of MBP, via binding to the gene promoter.
Protein Name Transcription Factor Sox-10
Database Links Reactome: R-HSA-9619665
Reactome: R-HSA-9764302
Cellular Localisation Cytoplasm
Nucleus
Mitochondrion Outer Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Alternative Antibody Names Anti-Transcription Factor Sox-10 antibody
Anti-SOX10 antibody

Information sourced from Uniprot.org

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