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| Short Description : | Mouse monoclonal anti-SOX-11 for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC-P |
| Host: | Mouse |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | MRQ-58 |
| Isotype: | IgG1 |
| Conjugation: | Unconjugated |
| Dilution Range: | IHC 1:25 – 1:100 |
| Formulation: | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Storage Instruction: | Store at 2-8°C for up to 1-year, upon receipt. |
| Background | SOX-11 which is a member of the SOX (SRY-related HMG-box) family is a transcription factor normally expressed in the developing human central nervous system and plays a role in embryonic cell determination. Studies show that SOX-11 can be used as a marker for mantle cell lymphoma (MCL). Mantle cell lymphoma (MCL) accounts for 5% to 10% of mature B-cell neoplasms and is an aggressive disease genetically characterized by overexpression of cyclin D1 (CCND1) , an important regulator of the G1/S phase of the cell cycle, due to the specific translocation t (11;14) (q13;q32). |
Information sourced from Uniprot.org
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