Host: | Mouse |
Applications: | IHC-P |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Mouse monoclonal antibody anti-SOX-11 is suitable for use in Immunohistochemistry research applications. |
Clonality : | Monoclonal |
Clone ID : | MRQ-58 |
Conjugation: | Unconjugated |
Isotype: | IgG1 |
Formulation: | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
Dilution Range: | IHC 1:25 – 1:100 |
Storage Instruction: | Store at 2-8°C upon receipt. |
Background | SOX-11 which is a member of the SOX (SRY-related HMG-box) family is a transcription factor normally expressed in the developing human central nervous system and plays a role in embryonic cell determination. Studies show that SOX-11 can be used as a marker for mantle cell lymphoma (MCL). Mantle cell lymphoma (MCL) accounts for 5% to 10% of mature B-cell neoplasms and is an aggressive disease genetically characterized by overexpression of cyclin D1 (CCND1) , an important regulator of the G1/S phase of the cell cycle, due to the specific translocation t (11;14) (q13;q32). |
Information sourced from Uniprot.org