| Short Description : | Rabbit polyclonal Sclerostin (24-213) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SOST |
| Gene ID: | 50964 |
| Uniprot ID: | SOST_HUMAN |
| Immunogen Region: | 24-213 |
| Immunogen Sequence: | QGWQAFKNDATEIIPELGEY PEPPPELENNKTMNRAENGG RPPHHPFETKDVSEYSCREL HFTRYVTDGPCRSAKPVTEL VCSGQCGPARLLPNAIGRGK WWRPSGPDFRCIPDRYRAQR VQLLCPGGEAPRARKVRLVA SCKCKRLTRFHNQSELKDFG TEAARPQKGRKPRPRARSAK ANQAELENAY |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-213 of human SOST (NP_079513.1). |
| Tissue Specificity | Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteoblasts differentiated for 21 days. Detected in the subendothelial layer of the aortic intima (at protein level). |
| Function | Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. |
| Protein Name | Sclerostin |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-3772470 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Sclerostin antibodyAnti-SOST antibodyAnti-UNQ2976 antibodyAnti-PRO7455 antibodyAnti-PRO7476 antibody |
Information sourced from Uniprot.org
