| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Sclerostin (24-213) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SOST |
| Gene ID: |
50964 |
| Uniprot ID: |
SOST_HUMAN |
| Immunogen Region: |
24-213 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 24-213 of human SOST (NP_079513.1). |
| Immunogen Sequence: |
QGWQAFKNDATEIIPELGEY PEPPPELENNKTMNRAENGG RPPHHPFETKDVSEYSCREL HFTRYVTDGPCRSAKPVTEL VCSGQCGPARLLPNAIGRGK WWRPSGPDFRCIPDRYRAQR VQLLCPGGEAPRARKVRLVA SCKCKRLTRFHNQSELKDFG TEAARPQKGRKPRPRARSAK ANQAELENAY |
| Tissue Specificity | Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteoblasts differentiated for 21 days. Detected in the subendothelial layer of the aortic intima (at protein level). |
| Function | Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. |
| Protein Name | Sclerostin |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-3772470 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Sclerostin antibodyAnti-SOST antibodyAnti-UNQ2976 antibodyAnti-PRO7455 antibodyAnti-PRO7476 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
