| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S4612RM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:2000-1:20000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SORD |
| Gene ID: | 6652 |
| Uniprot ID: | DHSO_HUMAN |
| Immunogen Region: | 100-200 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human Sorbitol Dehydrogenase (NP_003095.2). |
| Immunogen Sequence: | RENDEFCKMGRYNLSPSIFF CATPPDDGNLCRFYKHNAAF CYKLPDNVTFEEGALIEPLS VGIHACRRGGVTLGHKVLVC GAGPIGMVTLLVAKAMGAAQ V |
| Tissue Specificity | Expressed in liver. Expressed in kidney and epithelial cells of both benign and malignant prostate tissue. Expressed in epididymis (at protein level). |
| Function | Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is mostly active with D-sorbitol (D-glucitol), L-threitol, xylitol and ribitol as substrates, leading to the C2-oxidized products D-fructose, L-erythrulose, D-xylulose, and D-ribulose, respectively. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. The polyol pathway is believed to be involved in the etiology of diabetic complications, such as diabetic neuropathy and retinopathy, induced by hyperglycemia. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility. May have a more general function in the metabolism of secondary alcohols since it also catalyzes the stereospecific oxidation of (2R,3R)-2,3-butanediol. To a lesser extent, can also oxidize L-arabinitol, galactitol and D-mannitol and glycerol in vitro. Oxidizes neither ethanol nor other primary alcohols. Cannot use NADP(+) as the electron acceptor. |
| Protein Name | Sorbitol Dehydrogenase Sdh (R -R-Butanediol Dehydrogenase L-Iditol 2-Dehydrogenase Polyol Dehydrogenase Ribitol Dehydrogenase Rdh Xylitol Dehydrogenase Xdh |
| Database Links | Reactome: R-HSA-5652227 Reactome: R-HSA-5661270 |
| Cellular Localisation | Mitochondrion Membrane Peripheral Membrane Protein Cell Projection Cilium Flagellum Associated With Mitochondria Of The Midpiece And Near The Plasma Membrane In The Principal Piece Of The Flagellum Also Found In The Epididymosome Secreted By The Epididymal Epithelium And That Transfers Proteins From The Epididymal Fluid To The Sperm Surface |
| Alternative Antibody Names | Anti-Sorbitol Dehydrogenase antibody Anti-Sdh antibody Anti-(R -R-Butanediol Dehydrogenase antibody Anti-L-Iditol 2-Dehydrogenase antibody Anti-Polyol Dehydrogenase antibody Anti-Ribitol Dehydrogenase antibody Anti-Rdh antibody Anti-Xylitol Dehydrogenase antibody Anti-Xdh antibody Anti-SORD antibody |
Information sourced from Uniprot.org
