Anti-Somatostatin antibody (103-116) (STJA0040924)

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STJA0040924-50
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Host: Rabbit
Applications: ICC/IHC-F/IHC-P
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal anti-Somatostatin (103-116) for use in ICC, IHC-F and IHC-P in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Lyophilized with BSA.
Purification: Affinity-purified
Dilution Range: IHC 5-15 µg/mL
ICC 5-15 µg/mL
Storage Instruction: Spin vial briefly before opening. Reconstitute in 0.05 mL of sterile-filtered PBS (pH 7.4). Centrifuge to remove any insoluble material. At least 12 months after purchase at 2-8°C (lyophilized formulations). After reconstitution, aliquot and store at
Gene Symbol: SST
Gene ID: 6750
Uniprot ID: SMS_HUMAN
Immunogen Region: 103-116
Specificity: Human Somatostatin. Cross reactivity is expected with mouse, rat, other species not yet tested.
Immunogen: Synthetic Somatostatin peptide (103-116) conjugated to BSA.
Immunogen Sequence: Human
Post Translational Modifications C-terminal amidation of the neuronostatin peptide is required for its biological activity, including for the regulation of mean arterial pressure.
Function Somatostatin-14: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH.the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin. Neuronostatin: May enhance low-glucose-induced glucagon release by pancreatic alpha cells. This effect may be mediated by binding to GPR107 and PKA activation. May regulate cardiac contractile function. May compromise cardiomyocyte viability. In the central nervous system, may impair memory retention and may affect hippocampal excitability. May also have anxiolytic and anorexigenic effects. May play a role in arterial pressure regulation. May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH. Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH.
Protein Name Somatostatin
Growth Hormone Release-Inhibiting Factor Cleaved Into - Somatostatin-28 - Somatostatin-14
Sst-14 - Neuronostatin
Nst
Database Links Reactome: R-HSA-375276
Reactome: R-HSA-418594
Reactome: R-HSA-9022702
Cellular Localisation Secreted
Alternative Antibody Names Anti-Somatostatin antibody
Anti-Growth Hormone Release-Inhibiting Factor Cleaved Into - Somatostatin-28 - Somatostatin-14 antibody
Anti-Sst-14 - Neuronostatin antibody
Anti-Nst antibody
Anti-SST antibody

Information sourced from Uniprot.org

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