| Post Translational Modifications | Proteolytically cleaved in primary hepatocytes into a C-terminal 80 kDa form. Proteolytically cleaved into a C-terminal SOGA 25 kDa form that is detected in plasma. Phosphorylated during mitosis in a CDK1-dependent manner. |
| Function | Microtubule-associated factor that enables integration of the centrosomal and Golgi-associated microtubules on the Golgi membrane, supporting directional migration. Preferentially acts on the perinuclear microtubules accumulated around the Golgi. Associates with the Golgi membrane through the N-terminal coiled-coil region and directly binds microtubules through the C-terminal domain. Required for faithful chromosome segregation during mitosis. Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner. |
| Protein Name | Microtubule Cross-Linking Factor 2Soga Family Member 1Suppressor Of Glucose By AutophagySuppressor Of Glucose - Autophagy-Associated Protein 1 Cleaved Into - N-Terminal Form - C-Terminal 80 Kda Form80-Kda Soga Fragment |
| Cellular Localisation | CytoplasmCytoskeletonGolgi Apparatus MembraneMidbodyAssociates With Microtubules During Late Mitosis And InterphaseC-Terminal 80 Kda Form: SecretedSecreted In Primary Hepatocyte-Conditioned Media |
| Alternative Antibody Names | Anti-Microtubule Cross-Linking Factor 2 antibodyAnti-Soga Family Member 1 antibodyAnti-Suppressor Of Glucose By Autophagy antibodyAnti-Suppressor Of Glucose - Autophagy-Associated Protein 1 Cleaved Into - N-Terminal Form - C-Terminal 80 Kda Form antibodyAnti-80-Kda Soga Fragment antibodyAnti-MTCL2 antibodyAnti-C20orf117 antibodyAnti-KIAA0889 antibodyAnti-SOGA antibodyAnti-SOGA1 antibody |
Information sourced from Uniprot.org
