| Tissue Specificity | Expressed in brain and leukocytes. Also in fetal lung fibroblasts and fetal brain. |
| Function | Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DAB1 and IRS1. Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination. The ECS(SOCS7) complex acts as a key regulator of reelin signaling by mediating ubiquitination and degradation of phosphorylated DAB1 in the cortical plate of the developing cerebral cortex, thereby regulating neuron positioning during cortex development. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Also inhibits prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. |
| Protein Name | Suppressor Of Cytokine Signaling 7Socs-7Nck - Ash And Phospholipase C Gamma-Binding ProteinNck-Associated Protein 4Nap-4 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusCell MembranePeripheral Membrane ProteinCytoplasmic SideMostly CytoplasmicBut Shuttles Between The Cytoplasm And The NucleusRapidly Relocalizes To The Nucleus After Uv IrradiationCytoplasmic Location Depends Upon Sept7 Presence |
| Alternative Antibody Names | Anti-Suppressor Of Cytokine Signaling 7 antibodyAnti-Socs-7 antibodyAnti-Nck - Ash And Phospholipase C Gamma-Binding Protein antibodyAnti-Nck-Associated Protein 4 antibodyAnti-Nap-4 antibodyAnti-SOCS7 antibodyAnti-NAP4 antibodyAnti-SOCS6 antibody |
Information sourced from Uniprot.org
