| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SOCS6 |
| Gene ID: | 9306 |
| Uniprot ID: | SOCS6_HUMAN |
| Immunogen Region: | 1-210 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human SOCS6 (NP_004223.2). |
| Immunogen Sequence: | MKKISLKTLRKSFNLNKSKE ETDFMVVQQPSLASDFGKDD SLFGSCYGKDMASCDINGED EKGGKNRSKSESLMGTLKRR LSAKQKSKGKAGTPSGSSAD EDTFSSSSAPIVFKDVRAQR PIRSTSLRSHHYSPAPWPLR PTNSEETCIKMEVRVKALVH SSSPSPALNGVRKDFHDLQS ETTCQEQANSLKSSASHNGD LHLHLDEHVP |
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. |
| Protein Name | Suppressor Of Cytokine Signaling 6Socs-6Cytokine-Inducible Sh2 Protein 4Cis-4Suppressor Of Cytokine Signaling 4Socs-4 |
| Database Links | Reactome: R-HSA-1433559Reactome: R-HSA-8951664Reactome: R-HSA-9706369 |
| Alternative Antibody Names | Anti-Suppressor Of Cytokine Signaling 6 antibodyAnti-Socs-6 antibodyAnti-Cytokine-Inducible Sh2 Protein 4 antibodyAnti-Cis-4 antibodyAnti-Suppressor Of Cytokine Signaling 4 antibodyAnti-Socs-4 antibodyAnti-SOCS6 antibodyAnti-CIS4 antibodyAnti-SOCS4 antibody |
Information sourced from Uniprot.org