| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human/Mouse/Rat/Pig/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-SOCS5 (N-Term) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:64000.WB: Approx 65kDa band observed in lysates of cell line Molt4 (calculated MW of 61.2kDa according to NP_054730.1). Recommended concentration: 0.3-1µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | SOCS5 |
| Gene ID: | 9655 |
| Uniprot ID: | SOCS5_HUMAN |
| Immunogen Region: | N-Term |
| Accession Number: | NP_054730.1 |
| Specificity: | Both reported variants represent identical protein: NP_054730.1 and NP_659198.1. |
| Immunogen Sequence: | DKVGKMWNNFK |
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling. |
| Protein Name | Suppressor Of Cytokine Signaling 5Socs-5Cytokine-Inducible Sh2 Protein 6Cis-6Cytokine-Inducible Sh2-Containing Protein 5 |
| Database Links | Reactome: R-HSA-6785807Reactome: R-HSA-8951664 |
| Alternative Antibody Names | Anti-Suppressor Of Cytokine Signaling 5 antibodyAnti-Socs-5 antibodyAnti-Cytokine-Inducible Sh2 Protein 6 antibodyAnti-Cis-6 antibodyAnti-Cytokine-Inducible Sh2-Containing Protein 5 antibodyAnti-SOCS5 antibodyAnti-CIS6 antibodyAnti-CISH5 antibodyAnti-CISH6 antibodyAnti-KIAA0671 antibody |
Information sourced from Uniprot.org
