| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Sterol O-acyltransferase 2 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SOAT2 |
| Gene ID: | 8435 |
| Uniprot ID: | SOAT2_HUMAN |
| Specificity: | This antibody detects endogenous levels of SOAT2 at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human SOAT2 |
| Post Translational Modifications | Polyubiquitinated by AMFR/gp78 at Cys-277, leading to its degradation when the lipid levels are low. Association with AMFR/gp78 is mediated via interaction with INSIG1. High concentration of cholesterol and fatty acid results in Cys-277 oxidation, preventing ubiquitination at the same site, resulting in protein stabilization. Oxidized at Cys-277: high concentration of cholesterol and fatty acid induce reactive oxygen species, which oxidizes Cys-277, preventing ubiquitination at the same site, and resulting in protein stabilization. |
| Function | Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) and linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA) as substrates. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa. Isoform 2: Has lower enzymatic activity compared to isoform 1. Isoform 3: Has lower enzymatic activity compared to isoform 1. |
| Protein Name | Sterol O-Acyltransferase 2 Acyl-Coenzyme A -Cholesterol Acyltransferase 2 Acat-2 Cholesterol Acyltransferase 2 |
| Database Links | Reactome: R-HSA-8964038 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sterol O-Acyltransferase 2 antibody Anti-Acyl-Coenzyme A -Cholesterol Acyltransferase 2 antibody Anti-Acat-2 antibody Anti-Cholesterol Acyltransferase 2 antibody Anti-SOAT2 antibody Anti-ACACT2 antibody Anti-ACAT2 antibody |
Information sourced from Uniprot.org