| Host: |
Rabbit |
| Applications: |
WB/IHC/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Sorting Nexin-2 is suitable for use in Western Blot, Immunohistochemistry and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
| Purification: |
Affinity purification |
| Concentration: |
0.9 mg/mL |
| Dilution Range: |
WB 1:500-1:2000, IHC 1:25-1:100 |
| Storage Instruction: |
Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Gene Symbol: |
SNX2 |
| Gene ID: |
6643 |
| Uniprot ID: |
SNX2_HUMAN |
| Immunogen: |
Synthetic peptide of human SNX2 |
| Function | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Required for retrograde endosome-to-TGN transport of TGN38. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation.the function is dependent on GEF activity of KALRN. |
| Protein Name | Sorting Nexin-2Transformation-Related Gene 9 ProteinTrg-9 |
| Database Links | Reactome: R-HSA-432722 |
| Cellular Localisation | Early Endosome MembranePeripheral Membrane ProteinCytoplasmic SideCell ProjectionLamellipodiumColocalized With Sort1 To Tubular Endosomal Membrane Structures Called Endosome-To-Tgn Transport Carriers (Etcs) Which Are Budding From Early Endosome Vacuoles Just Before Maturing Into Late Endosome VacuolesColocalized With F-Actin At The Leading Edge Of Lamellipodia In Cells In A Kalrn-Dependent Manner |
| Alternative Antibody Names | Anti-Sorting Nexin-2 antibodyAnti-Transformation-Related Gene 9 Protein antibodyAnti-Trg-9 antibodyAnti-SNX2 antibodyAnti-TRG9 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
