| Function | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Required for retrograde endosome-to-TGN transport of TGN38. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation.the function is dependent on GEF activity of KALRN. |
| Protein Name | Sorting Nexin-2Transformation-Related Gene 9 ProteinTrg-9 |
| Database Links | Reactome: R-HSA-432722 |
| Cellular Localisation | Early Endosome MembranePeripheral Membrane ProteinCytoplasmic SideCell ProjectionLamellipodiumColocalized With Sort1 To Tubular Endosomal Membrane Structures Called Endosome-To-Tgn Transport Carriers (Etcs) Which Are Budding From Early Endosome Vacuoles Just Before Maturing Into Late Endosome VacuolesColocalized With F-Actin At The Leading Edge Of Lamellipodia In Cells In A Kalrn-Dependent Manner |
| Alternative Antibody Names | Anti-Sorting Nexin-2 antibodyAnti-Transformation-Related Gene 9 Protein antibodyAnti-Trg-9 antibodyAnti-SNX2 antibodyAnti-TRG9 antibody |
Information sourced from Uniprot.org
