Anti-SNX2 antibody (STJA0004330)

SKU:
STJA0004330

Current Stock:
Host: Rabbit
Applications: WB/IHC/ELISA
Reactivity: Human/Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Sorting Nexin-2 is suitable for use in Western Blot, Immunohistochemistry and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification: Affinity purification
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000, IHC 1:25-1:100
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Gene Symbol: SNX2
Gene ID: 6643
Uniprot ID: SNX2_HUMAN
Immunogen: Synthetic peptide of human SNX2
Function Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Required for retrograde endosome-to-TGN transport of TGN38. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation.the function is dependent on GEF activity of KALRN.
Protein Name Sorting Nexin-2
Transformation-Related Gene 9 Protein
Trg-9
Database Links Reactome: R-HSA-432722
Cellular Localisation Early Endosome Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Cell Projection
Lamellipodium
Colocalized With Sort1 To Tubular Endosomal Membrane Structures Called Endosome-To-Tgn Transport Carriers (Etcs) Which Are Budding From Early Endosome Vacuoles Just Before Maturing Into Late Endosome Vacuoles
Colocalized With F-Actin At The Leading Edge Of Lamellipodia In Cells In A Kalrn-Dependent Manner
Alternative Antibody Names Anti-Sorting Nexin-2 antibody
Anti-Transformation-Related Gene 9 Protein antibody
Anti-Trg-9 antibody
Anti-SNX2 antibody
Anti-TRG9 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance