| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SNRPE |
| Gene ID: | 6635 |
| Uniprot ID: | RUXE_HUMAN |
| Immunogen Region: | 1-92 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-92 of human SNRPE (NP_003085.1). |
| Immunogen Sequence: | MAYRGQGQKVQKVMVQPINL IFRYLQNRSRIQVWLYEQVN MRIEGCIIGFDEYMNLVLDD AEEIHSKTKSRKQLGRIMLK GDNITLLQSVSN |
| Tissue Specificity | Widely expressed. In scalp skin, it is present in the hair follicle, the epidermis, and the dermis. |
| Function | Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing. |
| Protein Name | Small Nuclear Ribonucleoprotein ESnrnp-ESm Protein ESm-ESme |
| Database Links | Reactome: R-HSA-111367Reactome: R-HSA-191859Reactome: R-HSA-72163Reactome: R-HSA-72165Reactome: R-HSA-73856Reactome: R-HSA-77588Reactome: R-HSA-9754678 |
| Cellular Localisation | CytoplasmCytosolNucleusSmn-Mediated Assembly Into Core Snrnps Occurs In The Cytosol Before Smn-Mediated Transport To The Nucleus To Be Included In Spliceosomes |
| Alternative Antibody Names | Anti-Small Nuclear Ribonucleoprotein E antibodyAnti-Snrnp-E antibodyAnti-Sm Protein E antibodyAnti-Sm-E antibodyAnti-Sme antibodyAnti-SNRPE antibody |
Information sourced from Uniprot.org