• Western blot analysis of various lysates using SNRPD3 Rabbit polyclonal antibody (STJ118510) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-SNRPD3 antibody (8-121) (STJ118510)

SKU:
STJ118510

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-SNRPD3 (8-121) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SNRPD3
Gene ID: 6634
Uniprot ID: SMD3_HUMAN
Immunogen Region: 8-121
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 8-121 of human SNRPD3 (NP_001265585).
Immunogen Sequence: KVLHEAEGHIVTCETNTGEV YRGKLIEAEDNMNCQMSNIT VTYRDGRVAQLEQVYIRGSK IRFLILPDMLKNAPMLKSMK NKNQGSGAGRGKAAILKAQV AARGRGRGMGRGNI
Post Translational Modifications Methylated on arginine residues by PRMT5 and PRMT7.probable asymmetric dimethylation which is required for assembly and biogenesis of snRNPs.
Function Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.
Protein Name Small Nuclear Ribonucleoprotein Sm D3
Sm-D3
Snrnp Core Protein D3
Database Links Reactome: R-HSA-111367
Reactome: R-HSA-191859
Reactome: R-HSA-72163
Reactome: R-HSA-72165
Reactome: R-HSA-73856
Reactome: R-HSA-77588
Reactome: R-HSA-9754678
Cellular Localisation Cytoplasm
Cytosol
Nucleus
Smn-Mediated Assembly Into Core Snrnps Occurs In The Cytosol Before Smn-Mediated Transport To The Nucleus To Be Included In Spliceosomes
Alternative Antibody Names Anti-Small Nuclear Ribonucleoprotein Sm D3 antibody
Anti-Sm-D3 antibody
Anti-Snrnp Core Protein D3 antibody
Anti-SNRPD3 antibody

Information sourced from Uniprot.org

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