| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Monoclonal |
| Clone ID: |
S5291RM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SNRNP70 |
| Gene ID: |
6625 |
| Uniprot ID: |
RU17_HUMAN |
| Immunogen Region: |
201-300 |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 201-300 of SNRNP70 (NP_003080.2). |
| Immunogen Sequence: |
RGGADVNIRHSGRDDTSRYD ERPGPSPLPHRDRDRDRERE RRERSRERDKERERRRSRSR DRRRRSRSRDKEERRRSRER SKDKDRDRKRRSSRSRERAR |
| Post Translational Modifications | The N-terminus is blocked. Extensively phosphorylated on serine residues in the C-terminal region. |
| Function | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. Isoform 3: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. Isoform 4: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. |
| Protein Name | U1 Small Nuclear Ribonucleoprotein 70 KdaU1 Snrnp 70 KdaU1-70kSnrnp70 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | Nucleus SpeckleNucleusNucleoplasmColocalizes With Scnm1 And Luc7l2 In Nuclear Speckles |
| Alternative Antibody Names | Anti-U1 Small Nuclear Ribonucleoprotein 70 Kda antibodyAnti-U1 Snrnp 70 Kda antibodyAnti-U1-70k antibodyAnti-Snrnp70 antibodyAnti-SNRNP70 antibodyAnti-RNPU1Z antibodyAnti-RPU1 antibodyAnti-SNRP70 antibodyAnti-U1AP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and SLC7A11/xCT knockdown (KD) HeLa cells using [KD Validated] SLC7A11/xCT Rabbit polyclonal antibody (STJ11105635) at 1:1000 dilution. Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/178279/370621/STJ11105635_1__38601.1713136567.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and SLC7A11/xCT knockdown (KD) HeLa cells using [KD Validated] SLC7A11/xCT Rabbit polyclonal antibody (STJ11105635) at 1:1000 dilution. Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.")
