Anti-SNF8 antibody (200-250) (STJ503494)

SKU:
STJ503494-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-SNF8 (200-250) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5-1.5 µg/µl
Dilution Range: WB: 1:2, 500-1:5, 000
ELISA: 1:50, 000
IP: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: SNF8
Gene ID: 11267
Uniprot ID: SNF8_HUMAN
Immunogen Region: 200-250
Immunogen: Synthetic peptide taken within amino acid region 200-250 on human Vacuolar-sorting Protein SNF8 protein.
Function Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. Required for the exosomal release of SDCBP, CD63 and syndecan.
Protein Name Vacuolar-Sorting Protein Snf8
Ell-Associated Protein Of 30 Kda
Escrt-Ii Complex Subunit Vps22
Hvps22
Database Links Reactome: R-HSA-917729
Reactome: R-HSA-9610379
Cellular Localisation Cytoplasm
Endosome Membrane
Nucleus
Late Endosome Membrane
Recruited To The Endosome Membrane To Participate In Vesicle Formation
Alternative Antibody Names Anti-Vacuolar-Sorting Protein Snf8 antibody
Anti-Ell-Associated Protein Of 30 Kda antibody
Anti-Escrt-Ii Complex Subunit Vps22 antibody
Anti-Hvps22 antibody
Anti-SNF8 antibody
Anti-EAP30 antibody

Information sourced from Uniprot.org

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