| Tissue Specificity | Ubiquitously expressed. |
| Post Translational Modifications | Phosphorylated by PIM1 in vitro. |
| Function | Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition. Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for STAT5. (Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2). (Microbial infection) Promotes SARS-CoV-2 RNA synthesis by binding to negative-sense RNA and the viral protein nsp9. |
| Protein Name | Staphylococcal Nuclease Domain-Containing Protein 1100 Kda CoactivatorEbna2 Coactivator P100Tudor Domain-Containing Protein 11P100 Co-Activator |
| Database Links | Reactome: R-HSA-6802952 |
| Cellular Localisation | CytoplasmNucleusMelanosomeIn Il-4 Stimulated Cells Colocalizes With Stat6 In The NucleusIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Antibody Names | Anti-Staphylococcal Nuclease Domain-Containing Protein 1 antibodyAnti-100 Kda Coactivator antibodyAnti-Ebna2 Coactivator P100 antibodyAnti-Tudor Domain-Containing Protein 11 antibodyAnti-P100 Co-Activator antibodyAnti-SND1 antibodyAnti-TDRD11 antibody |
Information sourced from Uniprot.org
![Immunohistochemistry analysis of paraffin-embedded human lung cancer using [KO Validated] SND1 rabbit polyclonal antibody (STJ28147) at dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/101484/389297/STJ28147_IHC_3__60225.1713158958.jpg?c=1 "Immunohistochemistry analysis of paraffin-embedded human lung cancer using [KO Validated] SND1 rabbit polyclonal antibody (STJ28147) at dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.")
![Immunohistochemistry analysis of paraffin-embedded mouse kidney using [KO Validated] SND1 rabbit polyclonal antibody (STJ28147) at dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/101484/389298/STJ28147_IHC_4__18105.1713158959.jpg?c=1 "Immunohistochemistry analysis of paraffin-embedded mouse kidney using [KO Validated] SND1 rabbit polyclonal antibody (STJ28147) at dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.")
![Immunohistochemistry analysis of paraffin-embedded rat colon using [KO Validated] SND1 rabbit polyclonal antibody (STJ28147) at dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/101484/389299/STJ28147_IHC_5__64932.1713158959.jpg?c=1 "Immunohistochemistry analysis of paraffin-embedded rat colon using [KO Validated] SND1 rabbit polyclonal antibody (STJ28147) at dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.")
![Immunohistochemistry analysis of paraffin-embedded rat kidney using [KO Validated] SND1 rabbit polyclonal antibody (STJ28147) at dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/101484/389300/STJ28147_IHC_6__32693.1713158960.jpg?c=1 "Immunohistochemistry analysis of paraffin-embedded rat kidney using [KO Validated] SND1 rabbit polyclonal antibody (STJ28147) at dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.")
