| Host: | Goat |
| Applications: | WB |
| Reactivity: | Human/Rat/Mouse/Monkey/Canine |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-SNCB (80 aa C-Term) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS, 20% Glycerol and 0.05% Sodium Azide. |
| Purification: | Epitope affinity purified |
| Concentration: | 2 mg/mL |
| Dilution Range: | WB 1:500-1:5000 |
| Storage Instruction: | For continuous use, store at 2-8 C for one-two days. For extended storage, store in-20 C freezer. Working dilution samples should be discarded if not used within 12 hours. |
| Gene Symbol: | SNCB |
| Gene ID: | 6620 |
| Uniprot ID: | SYUB_HUMAN |
| Immunogen Region: | 80 aa C-Term |
| Specificity: | Detects endogenous levels of SNCB by Western blot. This Ab is specific for SNCB and does not recognizes SNCA and SNCG proteins. |
| Immunogen: | Recombinant peptide derived from within residues 80 aa to the C-terminus of human SNCB produced in E. coli. |
| Immunogen Sequence: | SRETGLVKREEFPTDLKPEE VAQEAAEEPLIEPLMEPEGE SYEDPPQEEYQEYEPEA |
| Post Translational Modifications | Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II. |
| Function | Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease. |
| Protein Name | Beta-Synuclein |
| Database Links | Reactome: R-HSA-5660489 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Beta-Synuclein antibodyAnti-SNCB antibody |
Information sourced from Uniprot.org
