Anti-SNCAIP antibody (797-846 aa) (STJ95857)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human Synphilin-1 at the amino acid range 797-846
General Information
| Short Description | Rabbit polyclonal anti-Synphilin-1 (797-846 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SNCAIP |
| Gene ID | 9627 |
| Uniprot ID | SNCAP_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human Synphilin-1 at the amino acid range 797-846 |
| Immunogen Region | 797-846 aa |
| Specificity | Synphilin-1 Polyclonal Antibody detects endogenous levels of Synphilin-1 protein. |
Additional Info
| Post Translational Modifications | Ubiquitinated.mediated by SIAH1, SIAH2 or RNF19A and leading to its subsequent proteasomal degradation. In the absence of proteasomal degradation, ubiquitinated SNCAIP accumulates in cytoplasmic inclusion bodies. Isoform 2 is subject to limited ubiquitination that does not lead to proteasomal degradation. |
| Function | Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1. |
| Protein Name | Synphilin-1Sph1Alpha-Synuclein-Interacting Protein |
| Database Links | Reactome: R-HSA-977225 Q9Y6H5-2 |
| Cellular Localisation | CytoplasmDetected In Cytoplasmic Inclusion BodiesTogether With Snca |
| Alternative Antibody Names | Anti-Synphilin-1 antibodyAnti-Sph1 antibodyAnti-Alpha-Synuclein-Interacting Protein antibodyAnti-SNCAIP antibody |
Information sourced from Uniprot.org