| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SNAPIN (N-Term) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
SNAPIN |
| Gene ID: |
23557 |
| Uniprot ID: |
SNAPN_HUMAN |
| Immunogen Region: |
N-Term |
| Specificity: |
Specific for SNAPIN. |
| Immunogen: |
A synthetic peptide from n-terminal region of human SNAPIN (SNARE associated protein Snapin) conjugated to an immunogenic carrier protein was used as the antigen. |
| Post Translational Modifications | Phosphorylated by CSNK1D/CK1. Phosphorylated by PKD, phosphorylation controls SNAPIN protein stability. |
| Function | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. |
| Protein Name | Snare-Associated Protein SnapinBiogenesis Of Lysosome-Related Organelles Complex 1 Subunit 7Bloc-1 Subunit 7Synaptosomal-Associated Protein 25-Binding ProteinSnap-Associated Protein |
| Database Links | Reactome: R-HSA-432722 |
| Cellular Localisation | MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytosolPerinuclear RegionGolgi Apparatus MembraneLysosome MembraneCytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneColocalizes With Nanos1 And Pum2 In The Perinuclear Region Of Germ Cells |
| Alternative Antibody Names | Anti-Snare-Associated Protein Snapin antibodyAnti-Biogenesis Of Lysosome-Related Organelles Complex 1 Subunit 7 antibodyAnti-Bloc-1 Subunit 7 antibodyAnti-Synaptosomal-Associated Protein 25-Binding Protein antibodyAnti-Snap-Associated Protein antibodyAnti-SNAPIN antibodyAnti-BLOC1S7 antibodyAnti-SNAP25BP antibodyAnti-SNAPAP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
