• Immunohistochemical analysis of paraffin-embedded human oophoroma. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 45min).

Anti-SNAI2 antibody (197-247) (STJA0010247)

SKU:
STJA0010247

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/ELISA/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Zinc finger protein SNAI2 (197-247) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC-p 1:50-300
ELISA 2000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SNAI2
Gene ID: 6591
Uniprot ID: SNAI2_HUMAN
Immunogen Region: 197-247
Specificity: This antibody detects endogenous levels of Human, Mouse, Rat SNAI2
Immunogen: Synthesized peptide derived from human SNAI2 AA range: 197-247
Post Translational Modifications GSK3B-mediated phosphorylation results in cytoplasmic localization and degradation.
Function Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.
Protein Name Zinc Finger Protein Snai2
Neural Crest Transcription Factor Slug
Protein Snail Homolog 2
Database Links Reactome: R-HSA-8943724
Cellular Localisation Nucleus
Cytoplasm
Observed In Discrete Foci In Interphase Nuclei
These Nuclear Foci Do Not Overlap With The Nucleoli
The Sp100 And The Hp1 Heterochromatin Or The Coiled Body
Suggesting Snai2 Is Associated With Active Transcription Or Active Splicing Regions
Alternative Antibody Names Anti-Zinc Finger Protein Snai2 antibody
Anti-Neural Crest Transcription Factor Slug antibody
Anti-Protein Snail Homolog 2 antibody
Anti-SNAI2 antibody
Anti-SLUG antibody
Anti-SLUGH antibody

Information sourced from Uniprot.org

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