| Applications: | WB/IF/ICC/IP/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SMYD4 |
| Gene ID: | 114826 |
| Uniprot ID: | SMYD4_HUMAN |
| Immunogen Region: | 1-260 |
| Immunogen Sequence: | MDLPVDEWKSYLLQKWASLP TSVQVTISTAETLRDIFLHS SSLLQPEDELFLKRLSKGYL VGKDSDAPLFYREEGNKKFQ EKDYTGAAVLYSKGVSHSRP NTEDMSLCHANRSAALFHLG QYETCLKDINRAQTHGYPER LQPKIMLRKAECLVALGRLQ EASQTISDLERNFTATPALA DVLPQTLQRNLHRLKMKMQE KDSLTESFPAALAKTLEDAA LREENEQLSNASSSIGLCV |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human SMYD4 (NP_443160.2). |
| Function | Protein-lysine N-methyltransferase. Monomethylates PRMT5, modulating its transcriptional activity. May also act as a histone methyltransferase. Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1. |
| Protein Name | Protein-Lysine N-Methyltransferase Smyd4Set And Mynd Domain-Containing Protein 4 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Protein-Lysine N-Methyltransferase Smyd4 antibodyAnti-Set And Mynd Domain-Containing Protein 4 antibodyAnti-SMYD4 antibodyAnti-KIAA1936 antibody |
Information sourced from Uniprot.org
