| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SMURF1 (Internal Region) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1: 300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
SMURF1 |
| Gene ID: |
57154 |
| Uniprot ID: |
SMUF1_HUMAN |
| Immunogen Region: |
Internal Region |
| Specificity: |
Specific for SMUF1. |
| Immunogen: |
A synthetic peptide from internal region of mouse E3 ubiquitin protein ligase SMURF1 conjugated to an immunogenic carrier protein was used as the antigen. |
| Post Translational Modifications | Auto-ubiquitinated in presence of NDFIP1. Ubiquitinated by the SCF(FBXL15) complex at Lys-381 and Lys-383, leading to its degradation by the proteasome. Lys-383 is the primary ubiquitination site. |
| Function | E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS. Acts as an antagonist of TGF-beta signaling by ubiquitinating TGFBR1 and targeting it for degradation. Plays a role in dendrite formation by melanocytes. |
| Protein Name | E3 Ubiquitin-Protein Ligase Smurf1Hsmurf1Hect-Type E3 Ubiquitin Transferase Smurf1Smad Ubiquitination Regulatory Factor 1Smad-Specific E3 Ubiquitin-Protein Ligase 1 |
| Database Links | Reactome: R-HSA-201451Reactome: R-HSA-2173788Reactome: R-HSA-2173791Reactome: R-HSA-4608870Reactome: R-HSA-5632684Reactome: R-HSA-8939902Reactome: R-HSA-8941858Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Smurf1 antibodyAnti-Hsmurf1 antibodyAnti-Hect-Type E3 Ubiquitin Transferase Smurf1 antibodyAnti-Smad Ubiquitination Regulatory Factor 1 antibodyAnti-Smad-Specific E3 Ubiquitin-Protein Ligase 1 antibodyAnti-SMURF1 antibodyAnti-KIAA1625 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
