| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:3000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SMPD3 |
| Gene ID: | 55512 |
| Uniprot ID: | NSMA2_HUMAN |
| Immunogen Region: | 416-655 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 416-655 of human SMPD3 (NP_061137.1). |
| Immunogen Sequence: | MDVAYHCYPNKCNDDALASK GALFLKVQVGSTPQDQRIVG YIACTHLHAPQEDSAIRCGQ LDLLQDWLADFRKSTSSSSA ANPEELVAFDVVCGDFNFDN CSSDDKLEQQHSLFTHYRDP CRLGPGEEKPWAIGTLLDTN GLYDEDVCTPDNLQKVLESE EGRREYLAFPTSKSSGQKGR KELLKGNGRRIDYMLHAEEG LCPDWKAEVEEFSFITQLSG LTDHLPVAMRLMVSSGEEE |
| Tissue Specificity | Predominantly expressed in brain. |
| Post Translational Modifications | Palmitoylated, palmitoylation-deficient proteins are targeted for lysosomal degradation. |
| Function | Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization. Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location. May be involved in IL-1-beta-induced JNK activation in hepatocytes. May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions. |
| Protein Name | Sphingomyelin Phosphodiesterase 3 Neutral Sphingomyelinase 2 Nsmase-2 Nsmase2 Neutral Sphingomyelinase Ii |
| Database Links | Reactome: R-HSA-5626978 Reactome: R-HSA-9840310 |
| Cellular Localisation | Golgi Apparatus Membrane Lipid-Anchor Cell Membrane May Localize To Detergent-Resistant Subdomains Of Golgi Membranes Of Hypothalamic Neurosecretory Neurons Localizes To Plasma Membrane In Confluent Contact-Inhaibited Cells |
| Alternative Antibody Names | Anti-Sphingomyelin Phosphodiesterase 3 antibody Anti-Neutral Sphingomyelinase 2 antibody Anti-Nsmase-2 antibody Anti-Nsmase2 antibody Anti-Neutral Sphingomyelinase Ii antibody Anti-SMPD3 antibody |
Information sourced from Uniprot.org
