| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SMG5 (950-1016) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SMG5 |
| Gene ID: |
23381 |
| Uniprot ID: |
SMG5_HUMAN |
| Immunogen Region: |
950-1016 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 950-1016 of human SMG5 (NP_056142.2). |
| Immunogen Sequence: |
DSCKQLTLAQGAGEEDPSGM VTIITGLPLDNPSVLSGPMQ AALQAAAHASVDIKNVLDFY KQWKEIG |
| Tissue Specificity | Ubiquitous. |
| Function | Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity. |
| Protein Name | Nonsense-Mediated Mrna Decay Factor Smg5Est1-Like Protein BLpts-Rp1Lpts-Interacting ProteinSmg-5 HomologHsmg-5 |
| Database Links | Reactome: R-HSA-975957 |
| Cellular Localisation | CytoplasmNucleusPredominantly CytoplasmicAnd NuclearShuttles Between Nucleus And CytoplasmDetected In Cytoplasmic Mrna Decay Bodies |
| Alternative Antibody Names | Anti-Nonsense-Mediated Mrna Decay Factor Smg5 antibodyAnti-Est1-Like Protein B antibodyAnti-Lpts-Rp1 antibodyAnti-Lpts-Interacting Protein antibodyAnti-Smg-5 Homolog antibodyAnti-Hsmg-5 antibodyAnti-SMG5 antibodyAnti-EST1B antibodyAnti-KIAA1089 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
