| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Essential MCU regulator, mitochondrial (9-59 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SMDT1 |
| Gene ID: |
91689 |
| Uniprot ID: |
EMRE_HUMAN |
| Immunogen Region: |
9-59 aa |
| Specificity: |
This antibody detects endogenous levels of human CV032 |
| Immunogen: |
Synthesized peptide derived from the human CV032 at the amino acid range 9-59 |
| Function | Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria. Required to bridge the calcium-sensing proteins MICU1 and MICU2 with the calcium-conducting subunit MCU. Plays a central role in regulating the uniplex complex response to intracellular calcium signaling. Acts by mediating activation of MCU and retention of MICU1 to the MCU pore, in order to ensure tight regulation of the uniplex complex and appropriate responses to intracellular calcium signaling. |
| Protein Name | Essential Mcu Regulator - MitochondrialSingle-Pass Membrane Protein With Aspartate-Rich Tail 1 - Mitochondrial |
| Database Links | Reactome: R-HSA-8949215Reactome: R-HSA-8949664 |
| Cellular Localisation | Mitochondrion Inner MembraneSingle-Pass Membrane ProteinMaip1 Is Required To Assist Sorting Of Emre/Smdt1 Into Mitochondrion By Protecting Emre/Smdt1 Against Protein Degradation By Yme1l1Thereby Ensuring Smdt1/Emre Maturation By The Mitochondrial Processing Peptidase (Pmpca And Pmpcb) |
| Alternative Antibody Names | Anti-Essential Mcu Regulator - Mitochondrial antibodyAnti-Single-Pass Membrane Protein With Aspartate-Rich Tail 1 - Mitochondrial antibodyAnti-SMDT1 antibodyAnti-C22orf32 antibodyAnti-EMRE antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
